Meropenem Online



How and where to order Merrem, Meronem (Meropenem) IV injections 1 g per vial online on St. Ben's Clinic website:

Shop:MEDICINES STORE
Prices:from $49.95 per pack
Discount:10% coupon: MSD10
Forms:1 g per vial
Quantity:1, 2, 3 packs
Type:Meropenem brand, Merrem generic, Meronem generic
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Delivery:Regular airmail and express courier service
Shipping:Worldwide, including USA, UK, Europe, Canada, Australia


Meropenem (trade names include Merrem IV, Meronem IV, Merocrit, Meromac, Meroplan, Merotrol, Meroza, Optinem) is a broad-spectrum injectable antibiotic from carbapenems pharmacological group. This medication is used to treat many types of moderate to severe bacterial infections, such as bacterial meningitis, pneumonia, intra-abdominal infections, sepsis, septicaemia, anthrax, febrile neutropenia, lung infections in cystic fibrosis patients, complicated skin and skin structure infections, bladder, kidney and womb infections. The spectrum of action includes many Gram-positive and Gram-negative bacteria (including Pseudomonas) and anaerobic bacteria. It works as bactericide by killing sensitive bacteria, except against Listeria monocytogenes, where it is bacteriostatic.

Meronem (Meropenem) injections 1 g

Related medications:

  • Amoxicillin (Amoxil)
  • Ampicillin (Principen)
  • Azithromycin (Zithromax)
  • Betamipron, Panipenem (Carbenin)
  • Biapenem (Omegacin)
  • Chloramphenicol (Chloromycetin)
  • Cilastatin, Imipenem (Primaxin)
  • Cilastatin, Imipenem, Relebactam (Recarbrio)
  • Ciprofloxacin (Cipro)
  • Clarithromycin (Biaxin)
  • Clindamycin (Cleocin)
  • Doripenem (Doribax, Finibax)
  • Doxycycline (Vibramycin)
  • Ertapenem (Invanz)
  • Erythromycin (Ilosone)
  • Meropenem, Vaborbactam (Vabomere)
  • Minocycline (Minocin)
  • Moxifloxacin (Avelox)
  • Ofloxacin (Floxin)
  • Roxithromycin (Rulide)
  • Sulfamethoxazole, Trimethoprim (Bactrim)
  • Tebipenem Pivoxil (Orapenem)
  • Tetracycline (Sumycin)


    Pharmacological and medical categories:

  • Anti infective drugs
  • Antibacterial medications
  • Antibiotics
  • Beta-lactam antibacterials
  • Beta-lactams
  • Broad-spectrum antibiotics
  • Injectable antibiotics
  • Intravenous antibiotics


    ATC codes:

  • J - Antiinfectives for systemic use
  • J01 - Antibacterials for systemic use
  • J01D - Other beta-lactam antibacterials
  • J01DH - Carbapenems
  • J01DH02 - Meropenem


    ICD-10 codes:

  • Anthrax - A22
  • Other bacterial diseases - A30-A49
  • Other disorders of blood and blood-forming organs - D70-D77
  • Cystic fibrosis - E84
  • Inflammatory diseases of the central nervous system - G00-G09
  • Acute upper respiratory infection - J00-J06
  • Influenza and pneumonia - J09-J18
  • Infections of the skin and subcutaneous tissue - L00-L08
  • Diseases of the genitourinary system - N00-N99
  • Other disorders of urinary system - N39
  • Symptoms and signs involving the digestive system and abdomen - R10-R19


    Indications and usage:

    Merrem IV (Meropenem) is a penem antibacterial indicated for the treatment of:

  • Complicated skin and skin structure infections (adult patients and pediatric patients 3 months of age and older only).
  • Complicated intra-abdominal infections (adult and pediatric patients).
  • Bacterial meningitis (pediatric patients 3 months of age and older only).


    Dosage and administration:

  • Meropenem 500 mg every 8 hours by intravenous infusion over 15 to 30 minutes for complicated skin and skin structure infections (cSSSI) for adult patients. When treating infections caused by Pseudomonas aeruginosa, a dose of 1 gram every 8 hours is recommended.
  • Meropenem 1 gram every 8 hours by intravenous infusion over 15 minutes to 30 minutes for intra-abdominal infections for adult patients.
  • Meropenem 1 gram every 8 hours by intravenous bolus injection (5 mL to 20 mL) over 3 minutes to 5 minutes for adult patients.

    Dosage should be reduced in adult patients with renal impairment.


    Overdosage:

    In mice and rats, large intravenous doses of meropenem (2200 mg/kg to 4000 mg/kg) have been associated with ataxia, dyspnea, convulsions, and mortalities.

    Intentional overdosing of Merrem IV is unlikely, although accidental overdosing might occur if large doses are given to patients with reduced renal function. The largest dose of meropenem administered in clinical trials has been 2 grams given intravenously every 8 hours. At this dosage, no adverse pharmacological effects or increased safety risks have been observed.

    Limited postmarketing experience indicates that if adverse events occur following overdosage, they are consistent with the adverse event profile described in the Adverse Reactions section and are generally mild in severity and resolve on withdrawal or dose reduction. Consider symptomatic treatments. In individuals with normal renal function, rapid renal elimination takes place. Meropenem and its metabolite are readily dialyzable and effectively removed by hemodialysis; however, no information is available on the use of hemodialysis to treat overdosage.


    Dosage forms and strengths:

    Meropenem IV (Merrem, Meronem) 500 mg meropenem and 1 gram for injection in vials.


    Contraindications:

    Known hypersensitivity to product components or anaphylactic reactions to beta-lactams.


    Warnings and precautions:

  • Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving beta-lactams.
  • Severe cutaneous adverse reactions have been reported in patients receiving Merrem IV.
  • Seizures and other adverse CNS experiences have been reported during treatment.
  • Co-administration of Meropenem IV with valproic acid or divalproex sodium reduces the serum concentration of valproic acid potentially increasing the risk of breakthrough seizures.
  • Clostridium difficile-associated diarrhea (ranging from mild diarrhea to fatal colitis) has been reported. Evaluate if diarrhea occurs.
  • In patients with renal dysfunction, thrombocytopenia has been observed.


    Side effects, adverse reactions:

    Most common adverse reactions (2% or less) are: headache, constipation, diarrhea, anemia, nausea, vomiting, and rash.

    To report suspected adverse reactions, contact AstraZeneca, Pfizer companies or your local FDA.


    Drug interactions:

  • Co-administration of Merrem IV with probenecid inhibits renal excretion of meropenem and is therefore not recommended.
  • The concomitant use of Meropenem IV and valproic acid or divalproex sodium is generally not recommended. Antibacterial drugs other than carbapenems should be considered to treat infections in patients whose seizures are well controlled on valproic acid or divalproex sodium.


    Use in specific populations:

    Renal impairment: dose adjustment is necessary, if creatinine clearance is 50 mL/min or less.


    Patient counseling information:

  • Counsel patients that antibacterial drugs including Merrem IV should only be used to treat bacterial infections. They do not treat viral infections (e.g., the common cold). When Merrem IV is prescribed to treat a bacterial infection, tell patients that although it is common to feel better early in the course of therapy, take the medication exactly as directed. Skipping doses or not completing the full course of therapy may decrease the effectiveness of the immediate treatment and increase the likelihood that bacteria will develop resistance and will not be treatable by Meropenem IV or other antibacterial drugs in the future.
  • Counsel patients that diarrhea is a common problem caused by antibacterial drugs which usually ends when the antibacterial drug is discontinued. Sometimes after starting treatment with antibacterial drugs, patients can develop watery and bloody stools (with or without stomach cramps and fever) even as late as two or more months after having taken the last dose of the antibacterial drug. If this occurs, patients should contact their physician as soon as possible.
  • Counsel patients to inform their physician if they are taking valproic acid or divalproex sodium. Valproic acid concentrations in the blood may drop below the therapeutic range upon co-administration with Merrem IV. If treatment with this medication is necessary and continued, alternative or supplemental anti-convulsant medication to prevent and/or treat seizures may be needed.
  • Patients receiving Meropenem IV on an outpatient basis must be alerted of adverse events such as seizures, delirium, headaches and/or paresthesias that could interfere with mental alertness and/or cause motor impairment. Until it is reasonably well established that Merrem IV is well tolerated, patients should not operate machinery or motorized vehicles.


    Pregnancy categories:

  • B - Australia
  • C - United States (Risk cannot be ruled out)


    Salts and other forms:

  • Meropenem Base
  • Meropenem Anhydrous
  • Meropenem Hydrate
  • Meropenem Sodium
  • Meropenem Sodium Carbonate
  • Meropenem Trihydrate
  • Meropenem Trihydrochloride


    Synonyms, international and chemical names:

  • Meropeneemi
  • Meropenemum
  • Meropenemum Trihydricum


    Brands, generics, trade names:

  • Merocrit - Cipla
  • Meromac - Macleods Pharmaceuticals
  • Meronem - AstraZeneca
  • Meronem I.V. - AstraZeneca
  • Meropenem - Hospira, Sandoz
  • Meroplan - Abbott
  • Merotrol - Lupin Pharmaceuticals
  • Meroza - Zydus Cadila
  • Merrem - AstraZeneca, Pfizer
  • Merrem IV - AstraZeneca
  • Optinem - AstraZeneca


    APIs used in medicine in combinations with meropenem:

  • Clavulanic Acid
  • Sodium Chloride
  • Sulbactam
  • Vaborbactam


    Here is a list of popular medications containing meropenem as a main active pharmaceutical ingredient; their trade names, forms, doses, companies - manufacturers, distributors, suppliers, researchers and developers:

    Trade name of the drug Pharmaceutical forms and doses Companies
    Meronem
  • Injectable; Injection; Meropenem Trihydrate 25 mg / ml
  • Injectable; Injection; Meropenem Trihydrate 50 mg / ml
  • Injectable; Injection; Meropenem Trihydrate 500 mg
  • Injectable; Injection; Meropenem Trihydrate 1 g
  • AstraZeneca
  • Cana
  • Cooper Pharma
  • DKSH
  • Four Star
  • Spenser Pharma UK
  • Sumitomo Pharmaceuticals
  • Teva
  • Zuellig Pharma
  • Merrem
  • Injectable; Injection; Meropenem Trihydrate 25 mg / ml
  • Injectable; Injection; Meropenem Trihydrate 50 mg / ml
  • Injectable; Injection; Meropenem Trihydrate 500 mg
  • Injectable; Injection; Meropenem Trihydrate 1 g
  • AstraZeneca
  • Pfizer
  • Optinem
  • Injectable; Injection; Meropenem Trihydrate 25 mg / ml
  • Injectable; Injection; Meropenem Trihydrate 50 mg / ml
  • AstraZeneca



  • References:

  • Meropenem main article on Wikipedia: https://en.wikipedia.org/wiki/Meropenem
  • Meropenem compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Meropenem
  • Meropenem Trihydrate compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Meropenem-trihydrate
  • Meropenem on DrugBank: https://go.drugbank.com/drugs/DB00760
  • Meropenem Trihydrate on DrugBank: https://go.drugbank.com/salts/DBSALT002823
  • Meropenem Sodium on DrugBank: https://go.drugbank.com/salts/DBSALT002981
  • Meropenem Injection FAQ on MedlinePlus (revised 09/15/2016): https://medlineplus.gov/druginfo/meds/a696038.html
  • Merrem IV (Meropenem) injection drug label info on DailyMed (revised July 26, 2019): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
  • Meropenem injection drug label info on DailyMed (revised September 24, 2020): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
  • Meropenem containing drugs on Drugs-About.com: https://drugs-about.com/ing/meropenem.html
  • Meropenem for sale on Pharma Doctor: https://pharma-doctor.com/meropenem.html
  • Meropenem international drug names on Drugs.com: https://www.drugs.com/international/meropenem.html
  • Merrem IV (Meropenem for injection), for intravenous use official prescribing and patient counseling information from the U.S. FDA (revised 12/2016): https://www.accessdata.fda.gov/drugsatfda_docs/label...
  • Merrem IV (Meropenem) injections prescribing and patient counseling information from Pfizer pharmaceutical company (revised 04/2019): http://labeling.pfizer.com/ShowLabeling.aspx?id=9318
  • Meronem IV (Meropenem) 500 mg product information on Medicines.org.uk (revised 23 Dec 2019: https://www.medicines.org.uk/emc/medicine/11215
  • Meronem IV (Meropenem) 500 mg and 1 g powder for solution for injection or infusion package information leaflet on Medicines.org.uk (revised 02/2021): https://www.medicines.org.uk/emc/files/pil.6731.pdf

    Revised: June 2021



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